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https://www.nature.com/articles/s42004-022-00670-y?proof=t%7Bdb85a45b0718b17b43b3b0cb9ad96267d75ac4aa9054dd20a7983cf771540114%7D29&fbclid=IwAR0tBRbvSG9VjjlyuGGkaSiO90gGHsgCVT8XvTRTwattTwsqg8E6ySF9Cbo